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Posted by / 23-Jun-2017 09:34

I leave to anatomists equipped with more delicate instruments than I the task of elucidating this obscure question.

Understanding the genetic basis of disease is an important challenge in biology and medicine.

But that is not the question; the problem I have to elucidate!

Elucidate the accident, by which you had me kidnapped to be sold into slavery.

"; "Clear up the question of who is at fault"elaborate, expatiate, expound, lucubrate, dilate, flesh out, exposit, enlarge, expand - add details, as to an account or idea; clarify the meaning of and discourse in a learned way, usually in writing; "She elaborated on the main ideas in her dissertation"At the back of the estrade, and attached to a moveable partition dividing this schoolroom from another beyond, was a large tableau of wood painted black and varnished; a thick crayon of white chalk lay on my desk for the convenience of any grammatical or verbal obscurity which might occur in my lessons by writing it upon the tableau; a wet sponge appeared beside the chalk, to enable me to efface the marks when they had served the purpose intended.

The source code for GLADIATOR can be downloaded from A grand challenge of genetics and medicine is to further our understanding of the molecular basis of disease.

GLADIATOR relies on a gold-standard disease phenotypic similarity to obtain a pan-disease view of the underlying modules.

To traverse the search space of potential disease modules, we applied a simulated annealing algorithm aimed at maximizing the correlation between module similarity and the gold-standard phenotypic similarity.

Computational methods for associating genes with diseases often employ integrative approaches, exploiting different data sources such as Gene Ontology (GO) annotations [] created a statistical framework for constructing a sample-specific network describing an individual’s disease state.

The method compared gene expression correlations of a specific cell line to a background set and highlighted all edges in a PPI network in which gene expression correlation was dramatically altered.

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Partial collections of disease-related proteins, obtained using traditional and emerging high-throughput technologies, are available in public databases such as the Online Mendelian Inheritance in Man (OMIM) [].

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